Advil 12 Hour provides fast & effective relief of pain lasting longer than 6 hours. Advil 12 Hour is a bi-layer tablet that contains ibuprofen, 600mg (200 mg Immediate Release/400 mg Extended Release). The first layer dissolves quickly to relieve pain fast. The second layer is time-released to give relief that lasts up to 12 Hours. Advil 12 Hour offers convenient, 1 pill dosing.