Say goodnight to your aches and pains with Advil Nighttime. It contains the pain-relieving strength of Advil and helps you sleep. When you wake up tomorrow, you'll be ready to take on the day.


  • occasional mild to moderate nighttime pain and accompanying sleeplessness due to minor aches and pains associated with joints
  • muscles
  • backache
  • headache
  • toothache
  • pain of migraine
  • pain of arthritis

For use only if you have short-term nighttime pain causing sleeplessness. If this is not your case, do not use.

PURPOSE: Pain reliever / Sleep aid



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Directions For Use: 

Adults ≥16 to 65 years: Take a single dose of 1 or 2 Liqui-Gels at night. Do not take more than the recommended dosage unless directed by a doctor. Do not exceed 1200 mg of ibuprofen and 300 mg of diphenhydramine (including the 200-400 mg ibuprofen and 25-50 mg diphenhydramine hydrochloride from Advil Nighttime dose) in 24 hours. Should be taken no sooner than 4-6 hours after the last daytime ibuprofen or diphenhydramine dose. Do not take for more than 5 consecutive nights unless directed by a doctor.


Keep out of reach of children. This package contains enough medicine to seriously harm a child. Do not give to children under 16 unless directed by a doctor.


Do not take if you suffer from sleeplessness without pain, have pain that will not cause sleeplessness, if taking any other pain reliever, sleep aid, anti-nausea, or allergy medicine with antihistamines/pain relievers, or if allergic to ASA, salicylates, anti-inflammatory drugs, or any of the listed ingredients. May cause marked drowsiness. Consult your doctor before taking Advil Nighttime if you have peptic ulcers, high blood pressure, heart, kidney or liver disease, any other serious disease, or are taking any other drug. Do not take Advil Nighttime if you are pregnant or nursing a baby, unless directed by a doctor. Do not exceed the recommended dose unless advised by a doctor.

If abdominal pain, heartburn, nausea or vomiting, blood in vomit, bloating, diarrhea or constipation, ringing or buzzing in the ears, nervousness, dizziness or any change in vision, itching, fluid retention, skin rashes, bloody or black stools, bladder pain, hallucinations, difficulty speaking or any other side effect or unexplained symptoms develop, while taking Advil Nighttime, discontinue use immediately and contact a doctor. In case of accidental overdose, call a poison control centre or a doctor at once even if there are no symptoms.

Consult your doctor if the symptoms of pain or sleeplessness persist for more than 5 days.


Active Ingredient(s):

200 mg solubilized Ibuprofen (free acid and potassium salt); 25 mg Diphenhydramine Hydrochloride

Non-Medical Ingredients:

Coconut oil, D&C red no. 33, FD&C blue no. 1, gelatin, pharmaceutical ink, polyethylene glycol, potassium hydroxide, purified water, sorbitan, and sorbitol.

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Advil Nighttime package design

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Product package of Advil Nighttime



Advil Nighttime

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