Advil 12 Hour package design

Advil 12 Hour

New Advil 12 Hour is designed with dual-layer technology for up to 12 hours of pain relief in one hardworking pill. A quick burst for relief that’s fast. Extended release for relief that lasts.


  • Muscle pain
  • Back pain
  • Joint pain
  • Arthritis pain
  • Pain of inflammation
  • Swelling*

PURPOSE: Pain reliever / Fever reducer



Adults 18 years and older:

Take 1 tablet every 12 hours as needed. Do not exceed 2 tablets in 24 hours, unless directed by a doctor. For aches and pains that usually last longer than 6 hours. Do not use longer than 3 days for a fever or 5 days for pain relief. Do not take more than directed or more than 1 tablet at a time. Talk to your doctor if fever persists for more than 3 days, or pain for more than 5 days. Do not crush, chew or dissolve the tablet.


Keep out of reach of children. This package contains enough medicine to seriously harm a child.


Do not use this product if you are taking:

  • Daily low dose ASA (81 – 325 mg), without talking to a doctor or pharmacist. Ibuprofen may interfere with the preventative benefits of ASA.
  • ASA or other anti-inflammatory medication.

Talk to your doctor or pharmacist if you are taking other medication (prescription or non-prescription) such as any of the following (NOT a complete list): acetaminophen, anticoagulants (blood thinners), digoxin, oral antidiabetic agents and insulin, diuretics, methotrexate, lithium, protein-bound drugs including probenecid, thyroxine, antibiotics (e.g. cyclosporine), phenytoin, corticosteroids or benzodiazapenes, other NSAIDs, or medications for high blood pressure.


Active Ingredient(s): Ibuprofen Extended Release Tablets BP, 600mg


Carnauba wax, colloidal silicon dioxide, corn starch, croscarmellose sodium, hypromellose, microcrystalline cellulose, pharmaceutical ink, polydextrose, polyethylene glycol, pregelatinized starch, sodium lauryl sulfate, stearic acid, titanium dioxide.

For more information please see the product insert

Have questions about Advil products?

See our Frequently Asked Questions